Figure 1

Identification of a novel immunohistochemical marker DPEP1 to distinguish primary mucinous ovarian carcinomas from ovarian metastases of colorectal cancers. (a) Identification of genes differentially expressed in ovarian cancer and colorectal cancer. A total of 154 probes were selected using a cutoff of tenfold difference in expression. Gene expressions are log₂ transformed, centered, and normalized, and then the genes and tumor samples are ordered by an average-linkage hierarchical clustering. (b) Representative images of DPEP1 immunostaining in ovarian metastases of colorectal cancers and primary mucinous ovarian carcinomas. The percentage of positive tumor cells in the sample is indicated. (c) Number of samples with ≧25% or <25% DPEP1-positive tumor cells in primary mucinous ovarian carcinomas and ovarian metastases of colorectal cancers cases is shown.