Table 7 PCR results and comparison with MDM2 and CDK4 immunohistochemical status

From: MDM2 and CDK4 immunohistochemistry is a valuable tool in the differential diagnosis of low-grade osteosarcomas and other primary fibro-osseous lesions of the bone

Histological diagnosis

Total number of tumors

PCR results—MDM2 amplification

Immunohistochemistry

   

MDM2 expression

CDK4 expression

Fibrous and fibro-osseous bone lesions

16

0

0

0

High-grade primary bone sarcomas (two pleomorphic spindle cell sarcoma/malignant fibrous histiocytoma and one leiomyosarcoma)

3

0

0

0

  1. Abbreviations: CDK4, cyclin-dependent kinase 4; MDM2, murine double-minute type 2; PCR, polymerase chain reaction.
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