Table 1 Histopathologic features of 127 papillary lesions of the breast
From: Diagnostic evaluation of papillary lesions of the breast on core biopsy
Score | Histopathologic features | All | Benign | Atypical | Malignant | P-value a |
|---|---|---|---|---|---|---|
n (%) | n (%) | n (%) | n (%) | |||
Total number of cases | 127 | 78 | 26 | 23 | ||
Architectural features (n=127) | ||||||
1 | Papillary—single layer | 27 (21) | 26 (33) | 1 (4) | 0 (0) | <0.001 |
2 | Papillary—stratified | 22 (17) | 19 (24) | 2 (8) | 1 (4) | |
3 | Florid hyperplasia as seen in UDH | 44 (35) | 33 (42) | 11 (42) | 0 (0) | |
4 | Atypical architectural patterns as seen in ADH | 27 (21) | 0 (0) | 12 (46) | 15 (65) | |
5 | Solid | 7 (6) | 0 (0) | 0 (0) | 7 (30) | |
Extent of atypia (n=127) | ||||||
1 | None | 94 (74) | 78 (100) | 13 (50) | 3 (13) | <0.001 |
2 | Focal <30% of lesion | 8 (6) | 0 (0) | 8 (31) | 0 (0) | |
3 | Focal <60% of lesion | 2 (2) | 0 (0) | 1 (4) | 1 (4) | |
4 | Subtotal <90% of lesion | 4 (3) | 0 (0) | 3 (12) | 1 (4) | |
5 | Uniformly atypical | 19 (15) | 0 (0) | 1 (4) | 18 (78) | |
Myoepithelial cell layer (n=127) | ||||||
1 | Uniformly present | 82 (65) | 78 (100) | 4 (15) | 0 (0) | <0.001 |
2 | Focally absent | 26 (20) | 0 (0) | 16 (62) | 10 (43) | |
3 | Partly absent | 7 (6) | 0 (0) | 5 (19) | 2 (9) | |
4 | Completely absent | 12 (9) | 0 (0) | 1 (4) | 11 (48) | |
Nuclear features (cf normal epithelial cells) (n=127) | ||||||
1 | Small, uniform chromatin | 19 (15) | 13 (17) | 6 (23) | 0 (0) | <0.001 |
2 | Larger, chromatin margination, small nucleoli | 94 (74) | 63 (81) | 16 (62) | 15 (65) | |
3 | Larger, irregular chromatin, prominent nucleoli | 14 (11) | 2 (3) | 4 (15) | 8 (35) | |
Cell borders (n=126) | ||||||
1 | Distinct | 5 (4) | 0 (0) | 0 (0) | 5 (22) | <0.001 |
2 | Indistinct | 121 (96) | 77 (100) | 26 (100) | 18 (78) | |
Metaplasia (n=122) | ||||||
1 | None | 76 (62) | 45 (59) | 12 (50) | 19 (86) | 0.109 |
2 | Apocrine | 39 (32) | 27 (36) | 9 (38) | 3 (14) | |
3 | Sebaceous | 2 (2) | 1 (1) | 1 (4) | 0 (0) | |
4 | Mucinous | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
5 | Other | 5 (4) | 3 (4) | 2 (8) | 0 (0) | |
Fibrovascular cores (n=127) | ||||||
1 | Thin and arborizing | 83 (65) | 43 (55) | 20 (77) | 20 (87) | 0.006 |
2 | Broad and sclerotic (or both) | 44 (35) | 35 (45) | 6 (23) | 3 (13) | |
Epithelial entrapment in capsule (n=122) | ||||||
1 | Present | 60 (49) | 33 (43) | 17 (71) | 10 (48) | 0.053 |
2 | Absent | 62 (51) | 44 (57) | 7 (29) | 11 (52) | |
Perilesional sclerosis (n=127) | ||||||
1 | Minimal | 28 (22) | 18 (23) | 6 (23) | 4 (17) | 0.659 |
2 | Moderate | 76 (60) | 47 (60) | 13 (50) | 16 (70) | |
3 | Prominent | 23 (18) | 13 (17) | 7 (27) | 3 (13) | |
Surrounding breast changes (n=113) | ||||||
1 | Normal | 39 (35) | 28 (41) | 7 (28) | 4 (20) | 0.042 |
2 | Usual ductal hyperplasia | 17 (15) | 11 (16) | 4 (16) | 2 (10) | |
3 | Atypical ductal hyperplasia (ADH) | 3 (3) | 0 (0) | 1 (4) | 2 (10) | |
4 | Columnar cell lesionb | 43 (38) | 24 (35) | 9 (36) | 10 (50) | |
5 | Lobular carcinoma in situ | 0 (0) | 0 (0) | 0 (0) | 0 (0) | |
6 | DCIS | 4 (4) | 0 (0) | 3 (12) | 1 (5) | |
0 | Other | 7 (6) | 5 (7) | 1 (4) | 1 (5) | |
Epithelial CK5/6 staining (n=122) | ||||||
1 | Absent | 29 (24) | 2 (3) | 7 (30) | 20 (87) | <0.001 |
2 | Present | 93 (76) | 74 (97) | 16 (70) | 3 (13) | |
