Table 3 Genetic findings in CLL/SLL and histiocytic/dendritic cell neoplasms

From: Clonally related histiocytic/dendritic cell sarcoma and chronic lymphocytic leukemia/small lymphocytic lymphoma: a study of seven cases

Case

FISH analysis

Clonal Ig rearrangement by PCR a

Sequence identity between CLL/SLL and H/DC

 

6q−

11q−

12

13q−

17p−

  

1

 CLL/SLL

n

n

n

n

n

+

+

 H/DC

n

n

n

del

n

+

+

2

 CLL/SLL

n

n

n

n

n

+

+

 H/DC

n

n

n

n

a/du

+

+

3

 CLL/SLL

n

n

n

n

del

+b

ND

 H/DC

n

n

n

n

del

+b

ND

4

 CLL/SLL

n

n

n

n

n

+

ND

 H/DC

n

n

N

del

n

+

ND

5

 CLL/SLL

ND

ND

ND

ND

ND

+

+

 H/DC

ND

ND

ND

ND

ND

+

+

6

 CLL/SLL

n

n

n

n

n

+

+

 H/DC

a

a

a

a

a

+

+

7

 CLL/SLL

n

n

n

n

del

+

+

 H/DC

N

n

n

del

del

+

+

  1. CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; H/DC, histiocytic or dendritic cell neoplasm; n, normal; a, aneusomy; du, duplication; del, deletion; ND, not done.
  2. aClonal rearrangements identified with FR3 primer sets in all cases except case 3.
  3. bClonal rearrangement identified by IGK tube A primer sets.
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