Table 2 Significantly enriched Gene Ontology (GO) terms identified for genes overexpressed in human diffuse-type gastric adenocarcinomas
GO ID | GO term description | P-value | FDR corr. P-value | # in test list | # in ref. list |
|---|---|---|---|---|---|
GO:0031012 | Extracellular matrix | 8.43E−63 | 3.51E−60 | 137 | 484 |
GO:0005576 | Extracellular region | 5.99E−54 | 8.95E−52 | 189 | 1158 |
GO:0044421 | Extracellular region part | 5.99E−54 | 8.95E−52 | 189 | 1158 |
GO:0048856 | Anatomical structure development | 3.40E−45 | 4.27E−43 | 347 | 3798 |
GO:0032501 | Multicellular organismal process | 4.38E−44 | 4.58E−42 | 475 | 6245 |
GO:0007275 | Multicellular organismal development | 1.88E−42 | 1.69E−40 | 328 | 3584 |
GO:0032502 | Developmental process | 4.19E−39 | 3.22E−37 | 438 | 5787 |
GO:0022610 | Biological adhesion | 7.64E−38 | 5.14E−36 | 188 | 1529 |
GO:0048731 | System development | 4.72E−37 | 2.84E−35 | 300 | 3333 |
GO:0005578 | Proteinaceous extracellular matrix | 1.55E−34 | 8.48E−33 | 62 | 164 |
GO:0044420 | Extracellular matrix part | 2.71E−34 | 1.42E−32 | 62 | 166 |
GO:0009653 | Anatomical structure morphogenesis | 8.98E−31 | 4.24E−29 | 189 | 1768 |
GO:0048513 | Organ development | 2.87E−28 | 1.42E−26 | 229 | 2511 |
GO:0007155 | Cell adhesion | 1.86E−21 | 9.20E−20 | 100 | 776 |
GO:0005515 | Protein binding | 5.64E−19 | 2.59E−17 | 349 | 5332 |
GO:0003012 | Muscle system process | 6.78E−18 | 3.03E−16 | 53 | 281 |
GO:0005581 | Collagen | 1.15E−16 | 5.00E−15 | 24 | 46 |
GO:0030247 | Polysaccharide binding | 2.71E−16 | 1.09E−14 | 39 | 165 |
GO:0043062 | Extracellular structure organization and biogenesis | 3.90E−16 | 1.51E−14 | 42 | 196 |
GO:0001568 | Blood vessel development | 6.44E−16 | 2.29E−14 | 54 | 329 |
GO:0007399 | Nervous system development | 1.79E−15 | 6.59E−14 | 104 | 1031 |
GO:0001871 | Pattern binding | 5.15E−15 | 1.83E−13 | 39 | 183 |
GO:0030198 | Extracellular matrix organization and biogenesis | 7.25E−15 | 2.43E−13 | 20 | 34 |
GO:0001944 | Vasculature development | 1.10E−14 | 3.53E−13 | 57 | 392 |
GO:0022008 | Neurogenesis | 3.19E−14 | 1.00E−12 | 73 | 617 |
GO:0030246 | Carbohydrate binding | 1.14E−13 | 3.45E−12 | 59 | 443 |
GO:0000902 | Cell morphogenesis | 1.25E−13 | 3.72E−12 | 73 | 636 |
GO:0032989 | Cellular structure morphogenesis | 2.62E−13 | 7.43E−12 | 74 | 661 |
GO:0048699 | Generation of neurons | 2.93E−13 | 8.11E−12 | 68 | 577 |
GO:0030029 | Actin filament-based process | 4.65E−13 | 1.23E−11 | 60 | 473 |
GO:0009887 | Organ morphogenesis | 1.15E−12 | 2.97E−11 | 72 | 654 |
GO:0008092 | Cytoskeletal protein binding | 3.29E−12 | 8.16E−11 | 77 | 745 |
GO:0016477 | Cell migration | 3.78E−12 | 9.69E−11 | 59 | 486 |
GO:0035295 | Tube development | 5.58E−12 | 1.34E−10 | 47 | 332 |
GO:0031589 | Cell-substrate adhesion | 6.97E−12 | 1.61E−10 | 38 | 226 |
GO:0005539 | Glycosaminoglycan binding | 9.89E−12 | 2.28E−10 | 31 | 153 |
GO:0035239 | Tube morphogenesis | 1.11E−11 | 2.43E−10 | 38 | 230 |
GO:0022604 | Regulation of cell morphogenesis | 2.07E−11 | 4.38E−10 | 24 | 91 |
GO:0007154 | Cell communication | 2.32E−11 | 4.93E−10 | 392 | 6990 |
GO:0030182 | Neuron differentiation | 3.35E−11 | 7.04E−10 | 53 | 432 |
