Table 3 Differential THBS4 mRNA expression with respect to histological type of human gastric adenocarcinoma in three independent microarray data sets in comparison to this study

From: THBS4, a novel stromal molecule of diffuse-type gastric adenocarcinomas, identified by transcriptome-wide expression profiling

Diff. vs int.

Chen

Boussioutas

Hippo

Meta

This study

FC (log2)

1.44

0.96

1.12

1.17

5.35

P-value

1.95E−05***

0.0008***

0.1949

0.0001***

4.66E−12***

Q-value

0.0031

0.0195

0.8083

0.0078

8.19E−08

  1. Data were obtained fromhttp://human-genome.kribb.re.kr/stomach,36 an online service allowing the evaluation of single genes in the data of three major microarray studies on gastric adenocarcinoma10, 14, 53 and their meta-analysis. Statistical significance in differential expression was estimated by t-test (***P<0.001). Calculation of Q-values from the corresponding P-values was performed to control for the false discovery rate that occurs in multiple hypothesis testing.54 Meta-analysis of the data sets was performed as follows: The meta fold changes (FC) were calculated by taking an arithmetic mean of the individual values and meta P and Q-values were calculated by taking the arithmetic mean of log(P-values) and log(Q-values) of the individual data sets. The Q-value for THBS4 in this study was calculated using QVALUE software54,55 from the non-corrected P-value (P-values of all genes inputted).
Back to article page