Table 2 Predictive value of TP53 and CK7 to the presence of dysplasia

From: Diagnostic utility of TP53 and cytokeratin 7 immunohistochemistry in idiopathic inflammatory bowel disease-associated neoplasia

Variable

Cutoff

Sensitivity

Specificity

PPV

NPV

AUC a

TP53

8

0.6

0.87

0.83

0.67

0.75 (0.66–0.82)

CK7

30

0.63

0.72

0.72

0.64

0.65 (0.56–0.73)

TP53 and CK7

0.54b

0.68

0.85

0.82

0.71

0.81 (0.73–0.87)

TP53>8 and CK7>30

—

0.36

0.95

0.88

0.58

—

TP53>8 or CK7>30

—

0.82

0.56

0.66

0.75

—

  1. Abbreviations: AUC, area under the curve; NPV, negative predictive value; PPV, positive predictive value.
  2. aAUC (95% confidence interval).
  3. bCutoff for TP53 and CK7 was the probability of dysplasia predicted from the logistic regression model.
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