Table 4 Multivariate analysis in different subsets of lower-grade gliomas

Tumor subset	Variables	PFS		OS
		HR (95% CI) ^a	P	HR (95% CI) ^a	P
All lower-grade gliomas	Age ≤35 years	0.54 (0.37–0.79)	0.001	0.52 (0.34–0.78)	0.001
	WHO grade II	0.36 (0.24–0.54)	<0.001	0.28 (0.18–0.43)	<0.001
	Oligodendroglial	1	0.991	0.54	0.183
	Oligoastrocytic	0.87	0.579	0.82	0.464
	TERT promoter mutation	0.91	0.695	0.83	0.433
	IDH mutation	0.63 (0.43–0.91)	0.013	0.6 (0.41–0.88)	0.009
	1p/19q codeletion	0.49 (0.25–0.96)	0.036	0.47	0.06
IDH-mutated lower-grade gliomas	Age ≤35 years	0.55 (0.34–0.89)	0.015	0.51 (0.3–0.87)	0.013
	WHO grade II	0.39 (0.22–0.69)	0.001	0.3 (0.16–0.55)	<0.001
	Oligodendroglial	1.6	0.215	0.8	0.65
	Oligoastrocytic	1.13	0.675	1.15	0.645
	TERT promoter mutation	0.44 (0.24–0.8)	0.007	0.34 (0.18–0.66)	0.002
	1p/19q codeletion	0.5 (0.25–0.99)	0.047	0.46	0.057
IDH wild-type lower-grade gliomas	Age ≤35 years	0.91	0.762	0.93	0.829
	WHO grade II	0.36 (0.19–0.69)	0.002	0.29 (0.15–0.58)	<0.001
	Oligodendroglial	<0.001	0.974	<0.001	0.975
	Oligoastrocytic	0.54	0.29	0.37	0.186
	TERT promoter mutation	2.16 (1.09–4.28)	0.027	1.83	0.07

Abbreviations: 95%CI, 95% confidence interval; HR, hazard ratio; OS, overall survival; PFS, progression-free survival.
^a95% confidence intervals are shown for variables with significant P-value.

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