Figure 4 | Modern Pathology

Figure 4

From: Aberrant expression of annexin A10 is closely related to gastric phenotype in serrated pathway to colorectal carcinoma

Figure 4

Classification and regression tree (CART) model of immunohistochemical staining of annexin A10 (ANXA10), MUC5AC, MUC6 and high expression of CDX2. The model targets for molecular subgrouping of colorectal carcinomas with a statistical significance. The results indicated that ANXA10 was the most important partition factor. First split was created by the presence of ANXA10 expression and successfully separated the majority of subgroups 3 and 4 colorectal carcinomas from subgroups 1 and 2. The second and third nodes were split at MUC6 and MUC5AC expression, respectively, which made further contribution to molecular subclassification of the colorectal carcinomas in ANXA10-negative branch. CDX2 provided no significant contribution in the model.

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