Table 1 Histological reading template used for the analysis of gonads
From: A novel morphological approach to gonads in disorders of sex development
Type of gonad | Testis, ovary, ovotestis, streak |
Albuginea | Absence, presence/aspect, epithelial layer |
Architecture | Normal (regular lobules), abnormal (focal/diffuse) |
Interstitium | Normal or edematous, fibro-edematous, fibrous, fibroblastic (focal/diffuse) |
Leydig cells | Presence, absence, hyperplasia |
Seminiferous tubules | Morphology: normal (regular), abnormal (irregular/branched), diminished number, prepubertal or pubertal tubules |
Thickness of the lamina of the seminiferous tubules | |
Germ cells: normal, absence, hypoplasia; topography in the tubule | |
Presence of calcifications | |
Undifferentiated cords | With sex cords cells and/or germ cells |
Ovarian follicles | Presence, absence |
Pretumor lesions | Gonadoblastoma, germ cell neoplasia in situ |
Germ cell tumor | Presence, absence, type |
Other lesion | (Sertoli cells adenoma, hamartoma…) |
