Table 1 Characteristics of women diagnosed with colorectal cancer across tumor stromal and epithelial eosinophil scores^a

From: Tumor eosinophil infiltration and improved survival of colorectal cancer patients: Iowa Women’s Health Study

Participant’s characteristics	Stromal eosinophil score					Epithelial eosinophil score
	1 n=80	>1–2 n=164	>2–3 n=111	>3 n=86	P-value^b	1 n=250	>1–<2 n=114	≥2 n=77	P-value^b
Age at colorectal cancer diagnosis (years)
≤71	21.3	26.8	36.1	40.7		25.6	34.2	42.9
72–77	37.5	45.7	35.1	37.3		42.4	40.4	31.2
>77	41.3	27.4	28.8	22.1	0.02	32.0	25.4	26.0	0.05
BMI (kg/m²)^c
<25	27.5	37.2	36.0	46.5		36.8	35.1	40.3
25–30	37.5	39.0	33.3	25.6		36.8	31.6	33.8
>30	35.0	23.8	30.6	27.9	0.13	26.4	33.3	26.0	0.65
Smoking ^d
Current	12.7	14.7	13.6	15.7		13.8	13.1	17.3
Former	16.5	23.9	21.8	16.9		20.7	21.1	20.0
Never	70.9	61.4	64.6	67.5	0.76	65.5	65.8	62.7	0.95
History of diabetes ^c
Yes	13.8	12.8	17.1	17.4	0.68	21.6	15.8	16.9	0.36
History of hypertension ^c
Yes	48.8	43.9	50.5	52.3	0.57	45.6	43.9	62.3	0.02
History of heart disease ^c
Yes	25.0	15.9	24.3	14.0	0.10	21.6	15.8	16.9	0.36
Stage at diagnosis
In situ or local	20.0	30.5	33.3	45.4		28.6	41.2	32.4
Regional	48.8	46.3	35.1	32.6		46.4	29.0	41.6
Distant	20.0	12.2	13.5	8.1		13.5	12.3	13.0
Unknown	11.3	11.0	18.0	14.0	0.03	11.5	17.5	13.0	0.12
Grade
Well differentiated	3.8	4.9	6.3	7.0		5.2	6.1	5.2
Moderately differentiated	50.0	61.6	66.7	62.8		58.4	64.9	63.6
Poorly differentiated	41.3	29.3	23.4	24.4		31.2	24.6	28.6
Lymphomas/not stated	5.0	4.3	3.6	5.8	0.37	5.2	4.4	2.6	0.84
Colorectal cancer site
Colon proximal	63.8	60.4	52.3	43.0		56.0	53.5	58.4
Colon distal/rectal	33.8	37.8	47.8	55.8		42.4	44.8	41.6
Unspecified	2.5	1.8	0	1.2	0.04	1.6	1.7	0	0.80
Integrated pathway
Traditional	33.9	33.8	37.1	50.8		35.0	44.4	39.7
Alternate	6.8	13.2	7.9	15.9		9.4	14.8	12.7
Serrated	32.2	25.7	28.1	17.5		26.1	22.2	30.2
Unassigned	27.1	27.2	27.0	15.9	0.18	29.6	18.5	17.5	0.20
Surgery ^e
No	43.8	32.9	39.6	29.1		36.8	36.8	31.2
Yes	56.3	67.1	60.4	70.9	0.16	63.2	63.2	68.8	0.64
Chemotherapy ^e
No	73.7	78.1	78.4	81.4		78.8	79.0	74.0
Yes	26.3	21.9	21.6	18.6	0.70	21.2	21.1	26.0	0.65
Radiation ^e
No	96.1	97.6	95.4	97.6		96.3	96.4	98.7
Yes	3.9	2.4	4.6	2.4	0.25	3.7	3.6	1.3	0.59
Cytotoxic T-cell categories ^f
1						24.9	10.5	10.4
>1–2	37.9	27.7	13.8	14.0		42.9	38.6	29.9
>2–3	38.0	41.4	34.0	29.1		14.7	29.8	24.7
>3	24.1	30.9	52.3	57.0	0.0001	17.6	21.1	35.1	<0.0001

^aEpithelial and stromal eosinophil scores were assessed in epithelial and stromal areas of tumor, respectively.
^bThis is based on a chi-square test.
^cValue at the colorectal cancer diagnosis.
^dValue at baseline (in 1986).
^eInitial course of therapy.
^fCytotoxic T-cell (or CD8+ T cells) scores in epithelium and stroma were cross-tabulated with the corresponding eosinophil scores in epithelium and stroma. The categories in stromal cytotoxic T cells 1 and >1–2 were combined because of a very low frequency of stromal cytotoxic T cells in category=1.

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Table 1 Characteristics of women diagnosed with colorectal cancer across tumor stromal and epithelial eosinophil scores^a

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