Table 2 Hazard ratios for all-cause and colorectal cancer-specific death and 95% confidence intervals in relation to stromal eosinophil score^a in the colorectal cancer patients, Iowa Women’s Health Study.

Stromal eosinophil score	1	>1–2	>2–3	>3	P-trend
All-cause death
Five-year follow-up
No. of deaths (n=172)	41	74	34	23
Person-years	254	587	445	358
HR (95% CI)^b	Reference	0.83 (0.56–1.21)	0.51 (0.32–1.21)	0.44 (0.26–0.73)	0.0001
HR (95% CI)^c	Reference	0.97 (0.65–1.44)	0.68 (0.42–1.08)	0.61 (0.36–1.02)	0.02
HR (95% CI)^d	Reference	0.97 (0.65–1.44)	0.77 (0.47–1.25)	0.69 (0.40–1.19)	0.11
Total follow-up^e
No. of deaths (n=299)	56	123	72	48
Person-years	523	1267	998	892
HR (95% CI)^b	Reference	0.99 (0.72–1.36)	0.74 (0.52–1.05)	0.59 (0.40–0.87)	0.0009
HR (95% CI)^c	Reference	1.08 (0.78–1.50)	0.88 (0.61–1.27)	0.72 (0.48–1.08)	0.04
HR (95% CI)^d	Reference	1.07 (0.77–1.50)	0.95 (0.65–1.38)	0.79 (0.52–1.20)	0.18
Colorectal cancer death
Five-year follow-up
No. deaths (n=121)	30	53	25	13
Person-years	254	587	445	358
HR (95% CI)^b	Reference	0.77 (0.49–1.21)	0.49 (0.29–0.84)	0.32 (0.17–0.62)	<.0001
HR (95% CI)^c	Reference	0.96 (0.60–1.52)	0.70 (0.41–1.22)	0.48 (0.24–0.93)	0.01
HR (95% CI)^d	Reference	0.97 (0.61–1.55)	0.84 (0.47–1.49)	0.57 (0.29–1.15)	0.11
Total follow-up ^e
No. of deaths (n=138)	30	61	29	18
Person-years	523	1267	998	892
HR (95% CI)^b	Reference	0.88 (0.57–1.37)	0.56 (0.34–0.94)	0.43 (0.24–0.77)	0.0005
HR (95% CI)^c	Reference	1.05 (0.67–1.64)	0.76 (0.45–1.29)	0.61 (0.34–1.12)	0.04
HR (95% CI)^d	Reference	1.07 (0.68–1.68)	0.92 (0.53–1.59)	0.75 (0.40–1.41)	0.31

^aStromal eosinophil score was assessed in stromal area of tumor.
^bModel 1: Adjusted for age.
^cModel 2: Model 1+BMI, smoking status, stage, and grade at diagnosis.
^dModel 3: Model 2+cytotoxic T-cell (also called CD8+) score.
^eTotal follow-up lasted from the date of diagnosis until death or the end of this study in 2011.

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