Table 3 Hazard ratios for all-cause and colorectal cancer death and 95% confidence intervals in relation to epithelial eosinophil score^a in the colorectal cancer patients, Iowa Women’s Health Study

Epithelial eosinophil score	1	>1–<2	≥2	P-trend
All-cause death
Five-year follow-up
No. of deaths (n=172)	108	39	25
Person-years	884	450	309
HR (95% CI)^b	Reference	0.74 (0.51–1.06)	0.69 (0.44–1.06)	0.04
HR (95% CI)^c	Reference	0.91 (0.63–1.33)	0.74 (0.48–1.15)	0.18
HR (95% CI)^d	Reference	0.95 (0.65–1.38)	0.82 (0.52–1.29)	0.40
Total follow-up ^e
No. of deaths (n=299)	180	74	45
Person-years	1899	1039	739
HR (95% CI)^b	Reference	0.81 (0.61–1.06)	0.68 (0.49–0.95)	0.01
HR (95% CI)^c	Reference	0.92 (0.69–1.22)	0.74 (0.53–1.03)	0.08
HR (95% CI)^d	Reference	0.92 (0.69–1.22)	0.79 (0.56–1.12)	0.22
Colorectal cancer death
Five-year follow-up
No. of deaths (n=121)	77	30	14
Person-years	884	450	309
HR (95% CI)^b	Reference	0.78 (0.51–1.19)	0.53 (0.30–0.94)	0.02
HR (95% CI)^c	Reference	1.03 (0.67–1.58)	0.58 (0.33–1.03)	0.11
HR (95% CI)^d	Reference	1.08 (0.70–1.67)	0.70 (0.39–1.26)	0.36
Total follow-up^e
No. of deaths (n=138)	85	33	20
Person-years	1899	1039	739
HR (95% CI)^b	Reference	0.76 (0.50–1.14)	0.67 (0.41–1.09)	0.07
HR (95% CI)^c	Reference	0.98 (0.65–1.48)	0.74 (0.45–1.20)	0.27
HR (95% CI)^d	Reference	1.02 (0.67–1.54)	0.88 (0.53–1.46)	0.69

^aEpithelial eosinophil score was assessed in epithelial area of tumor.
^bModel 1: Adjusted for age.
^cModel 2: Adjusted for age of diagnosis, BMI, smoking status, stage and grade at diagnosis.
^dModel 3: Model 2+cytotoxic T-cell (also called CD8+) score.
^eTotal follow-up lasted from the date of diagnosis through death or the end of this study in 2011.

Search