Figure 1 | Modern Pathology

Figure 1

From: Analytic validation of a clinical-grade PTEN immunohistochemistry assay in prostate cancer by comparison with PTEN FISH

Figure 1

Prostate cancer cases showing intact PTEN protein with two intact PTEN gene alleles. Cases #1 and 2: PTEN immunohistochemistry demonstrates intact PTEN protein (left), while four-color FISH image from adjacent section (right) shows two intact PTEN alleles (see enlarged inset–two red signals) with two intact copies flanking genes WAPAL (green) and FAS (aqua) as well as chromosome 10 centromeres (pink).

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