Figure 2
From: Molecular testing for the clinical diagnosis of fibrolamellar carcinoma
Typical fibrolamellar carcinoma results. (a) Typical fibrolamellar carcinoma. The neoplastic cells are characterized by abundant eosinophilic cytoplasm, nuclei with open chromatin, and prominent nucleoli. The tumor cells form trabecula which are separated by bands of fibrosis. (b) Cytokeratin 7 is positive in the tumor cells. (c) A CD68 immunostain shows characteristic cytoplasmic staining. (d) PRKACA break apart FISH in a typical fibrolamellar carcinoma. The FISH result is positive. The tumor cells show separate green signals and intact yellow signals (due to overlapping red and green signals).
