Figure 4
From: Molecular testing for the clinical diagnosis of fibrolamellar carcinoma
Fibrolamellar carcinoma with uncommon FISH results (a) PRKACA break-apart FISH shows separate red and green signals in a morphologically typical fibrolamellar carcinoma. This FISH signal pattern raised the possibility of either a different fusion partner for PRKACA or heterozygous loss of the PRKACA locus without involvement in a gene fusion event. (b). Array comparative genomic hybridization data at chromosome 19p demonstrated heterozygous loss of the PRKACA locus due to a 10 Mb deletion (orange bidirectional arrow) including the hybridization site of the FISH probe (shown in green).
