Figure 5
From: Molecular testing for the clinical diagnosis of fibrolamellar carcinoma

Possible fibrolamellar carcinoma. An example of a case classified as a ‘possible fibrolamellar carcinoma’ based on morphology, characterized by intratumoral fibrosis and neoplastic cells with granular cytoplasm. The cytoplasm of the tumor cells is amphophilic in nature. This case was positive for PRKACA break-apart by FISH testing.