Table 2 Clinical, morphologic, and immunophenotypic features of de novo pure erythroid leukemia
Case | Age (years) | Gender | Peripheral blood: pancytopenia | Peripheral blood: bicytopenia (anemia and thrombocytopenia) | Peripheral blood: circulating erythroblasts (%) | Bone marrow: cellularity (%) | Bone marrow: % red blood cell precursors (not pronormoblasts)/% pronormoblasts (based on aspirate or core) | Bone marrow: % myeloid blasts of total nucleated elements a | Immunophenotypic characteristics of the myeloid (non-erythroid) blasts (determined by flow cytometry); positive for |
|---|---|---|---|---|---|---|---|---|---|
1 | 61 | M | + | None | 95 | 17/67 (aspirate) | <1 | CD45 (dim), CD34, CD117, CD13, CD33, CD7, HLA-DR | |
2 | 57 | M | + | None | 80 | 30/55 (core) | <5 | CD45 (dim), CD34, CD117, CD13, CD33, HLA-DR | |
3 | 78 | M | WBC 7.6 | 4 | 90 | 0/85 (core) | <2 | No myeloblasts detected | |
4 | 70 | M | WBC 6.4 | 5 | 95 | 20/70 (core) | <2 | CD45 (dim), CD117, CD13, CD33, CD38, MPO | |
5 | 68 | F | WBC 5.9 | 1 | 50 | 50/31 (aspirate) | 3 | CD45 (dim), CD34, CD117, CD13, CD33, HLA-DR, CD38 | |
6 | 47 | F | WBC 4.3 | Rare | 70 | 3/81 (aspirate) | <1 | No myeloblasts detected | |
7 | 62 | M | + | Rare | 95 | 20/70 (core) | Rare | No myeloblasts detected | |
8 | 68 | M | WBC 32.6b | None | 70 | 40/50 (core) | <5 | Flow only performed for CLL | |
9 | 80 | M | + | 5 | 80 | 0/90 (core) | Rare | No myeloblasts detected | |
10 | 78 | M | + | 61 | 95 | 31/59 (aspirate) | 5 | CD45 (dim), CD34, CD117, CD13, HLA-DR, CD38 | |
11 | 87 | M | NA | Rare | 90 | 0/81 (aspirate) | 1 | CD45 (dim), CD34, CD117, CD33, HLA-DR, CD38 | |
12 | 60 | M | + | None | 70 | 27/60 (aspirate) | 2 | CD45 (dim), CD34, CD117, CD13 (partial), CD33 (partial), HLA-DR, CD38 | |
13 | 79 | M | + | 3 | 50 | 15/75 (core) | Rare | CD45 (dim), CD34, CD13, CD33, CD117, HLA-DR, CD38 | |
14 | 70 | F | WBC 6.4 | Rare | 95 | 50/40 (core) | <5 | Flow not performed | |
15 | 60 | M | WBC 6.3 | None | 95 | 1/84 (aspirate) | 0 | No myeloblasts detected |
