Table 1 Demographic and laboratory data of myeloma patients with TP53 deletion and either normal karyotype (NK) or complex karyotype (CK)
From: Clinical implications of cytogenetic heterogeneity in multiple myeloma patients with TP53 deletion
Normal karyotype, (N=14) Median (range) | Complex karyotype, (N=73) Median (range) | P-v alue* | |
|---|---|---|---|
Age | 57 (38–68) | 58 (38–84) | 0.31 |
M:F ratio | 1.3 | 1.5 | NA |
Hemoglobin (g/dl) | 11 (7.5–13.8) | 10 (6.0–14.2) | 0.11 |
Plasma cells in bone marrow aspirate (%) | 54 (30–90) | 78 (30–96) | 0.003 |
Albumin (g/dl) | 3.7 (2.7–4.3) | 4.0 (2–5.0) | 0.89 |
Beta-2 microglobulin (mg/l) | 3.3 (1.6–9.9) | 5.0 (2.0–90.4) | <0.001 |
Creatinine | 1.2 (0.5–2.3) | 1.0 (0.3–7.4) | 0.443 |
Lactate dehydrogenase (IU/l) | 495 (265–786) | 564 (243–12766) | 0.015 |
TP53 deletion clone size (%) by FISH | 12.8 (8–40) | 30 (5–95) | <0.001 |
