Figure 3
A single injection of amylin or pramlintide induces a change of serum Aβ in the amyloid precursor protein (APP) transgenic mice. After one intraperitoneal (i.p.) injection of phosphate-buffered saline vs amylin (a) or pramlintide (b) (200 μg kg−1) in Tg2576 mice, changes in levels of serum Aβ1–42 and Aβ1–40 were observed. A single i.p. injection of amylin induced an increase in serum Aβ1–42 but not Aβ1–40 in 5XFAD mice (c); in contrast, i.p. injection of amylin induced an increase in serum Aβ1–40 but not Aβ1–42 in Dutch APP mice (d). In 5XFAD mice, the changes in serum Aβ1–42 in response to a challenge with amylin were dose dependent (e). Significance of changes in Aβ levels before and after the injection was determined by Student’s t-test. *P<0.05.
