Figure 4
Change in serum Aβ levels induced by amylin challenge and Aβ pathology in the brain. Serum samples were isolated before and after 5XFAD mice, which were at different ages, were challenged by a single intraperitoneal (i.p.) injection of amylin. The mice were killed immediately after the amylin challenge procedure, and the brain protein was extracted. The percentage of changes in serum Aβ1–42 induced by a single i.p. injection of amylin significantly correlated with the amounts of Aβ1–42 in their brains (r=0.83, P=6.7 × 10−6) (a). Amylin-induced serum Aβ1-42 changes induced by i.p. injection or intracerebroventricular (i.c.v.) injection in the 5XFAD mice were compared (b). Higher levels of increased serum Aβ1–42 induced by i.c.v. injection of amylin than by i.p. injection of amylin were observed (P=0.03) in these mice.
