Table 1 Correlations between Aβ and amylin in plasma in humans

From: Intraperitoneal injection of the pancreatic peptide amylin potently reduces behavioral impairment and brain amyloid pathology in murine models of Alzheimer’s disease

Diagnoses

Controls, N=145

Amnestic, MCI N=16

Alzheimer’s disease, N=42

Age, year, mean±s.d.*

72.3±8.0

75.7±8.7

80.5±8.1

MMSE, mean±s.d.*

27.1±2.6

26.4±2.5

22.2±3.3

Log10 amylin with Log10 Aß1-42

r=+0.06, P=0.46

r=+0.73, P=0.001

r=+0.52, P=0.0004

Log10 amylin with Log10 Aß1-40

r=+0.02, P=0.83

r=+0.58, P=0.02

r=+0.29, P=0.06

  1. Abbreviations: MCI, mild cognitive impairment; MMSE, Mini Mental State Exam.
  2. Using analysis of variance, age and average MMSE scores in the subgroups of the controls, amnestic MCI and Alzheimer’s disease are compared. *P<0.0001. Pearson's analyses were performed to determine the correlation coefficient between plasma Aβ40 or Aβ42 and amylin in different subgroups: the controls, amnestic MCI and Alzheimer’s disease. P-values for statistical significance are shown.
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