Figure 2
Brain areas where relative activity changed after levothyroxine (L-T4) treatment or placebo. Colors superimposed on a gray-scale structural magnetic resonance template indicate areas where relative metabolism decreased after, as compared with that before treatment (t⩾1.69; P<0.05), in bipolar disorder patients treated with L-T4 (top row), placebo (center row), or where the decrease was greater in the L-T4 than placebo group (bottom row). Coordinates are in Montreal Neurological Institute (MNI) space depicted in neurological orientation. PLA, placebo.
