Molecular Psychiatry

Table 2 Positive covariation between change in mood (HamD) and change of relative activity after treatment

From: Levothyroxine effects on depressive symptoms and limbic glucose metabolism in bipolar disorder: a randomized, placebo-controlled positron emission tomography study

			L-T4 treatment group						Placebo group						Group difference (L-T4>placebo)
		Search	VOI	Peak					VOI	Peak					VOI	Peak					No. of voxels <0.05
	VOI	Volume	P<0.05 (%)	t	P-FWE	x	y	z	P<0.05 (%)	t	P-FWE	x	y	z	P<0.05 (%)	t	P-FWE	x	y	z	L-T4	PLA	L-T4>P
L	Thalamus	1365	91	6.04	0.001	−20	−16	4	3						37	3.73	0.045	−20	−18	2	1241	40	502
R	Thalamus	1216	98	4.62	0.007	20	−16	14	0						58	4.00	0.025	16	−6	2	1192	0	707
L	Amygdala	154	88	2.91	0.040	−28	0	−24	0						7						136	0	11
R	Amygdala	161	97	3.63	0.011	24	−6	−14	0						0						156	0	0
L	Hippocampus	246	93	3.24	0.041	−22	−12	−24	0						26						230	0	64
R	Hippocampus	333	95	3.98	0.011	36	−22	−16	2						4						317	7	12
L	Ventral striatum	208	54	3.06	0.041	−14	4	−14	0						28	3.29	0.026	−28	8	−8	113	0	59
R	Ventral striatum	184	53	4.09	0.005	8	4	−8	0						7						97	0	13
L	Dorsal striatum	1054	79	5.27	0.002	−16	−8	20	0						20						831	5	214
R	Dorsal striatum	1149	88	4.63	0.009	16	0	16	0						28						1012	1	320
	Subgenual cingulate	904	66	4.94	0.003	−2	26	−18	7						10						593	60	88
	Cerebellar Vermis	375	92	3.84	0.022	4	−62	−26	3						13						375	13	48
					12/12 at 0.05																86%	2%	28%

Abbreviations: FWE, family-wise error; HamD, Hamilton Rating Scale for Depression; L, left; L-T4, levothyroxine; PLA, placebo; R, right; VOI, volume of interest.
Bold values indicate 0.05/12=0.0042.

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