Table 1 Clusters showing differences between MDD and controls that met our criteria for robustness
Peak MNI coordinate | Z | P | Voxels | Brodmann areas | Regions |
|---|---|---|---|---|---|
MDD<Healthy controls | |||||
−42, 8, −2 | 4.05 | <0.001 | 3258 | 22, 38, 48 | Left insula, inferior frontal gyrus, temporal pole, superior temporal gyrus |
54, −8, −14 | 4.00 | <0.001 | 1912 | 21, 22, 48 | Right superior temporal gyrus, insula, inferior frontal gyrus |
−2, 40, −18 | 3.40 | <0.001 | 908 | 11 | Left gyrus rectus, left medial orbitofrontal cortex, anterior cingulate cortex |
0, 4, 42 | 3.34 | <0.001 | 729 | 23, 24 | Left middle cingulate cortex |
−10, 16, 6 | 3.53 | <0.001 | 320 | 25 | Left caudate nucleus |
44, 48, −8 | 3.12 | <0.001 | 282 | 46, 47 | Right middle frontal gyrus, orbital part |
32, 42, 30 | 3.10 | <0.001 | 144 | 46 | Right middle frontal gyrus |
−28, −38, −4 | 2.88 | 0.001 | 104 | 37 | Left hippocampus, parahippocampal gyrus |
−40, −54, 46 | 3.21 | <0.001 | 93 | 40 | Left inferior lobule |
44, −24, −24 | 2.78 | 0.001 | 92 | 20 | Right fusiform gyrus |
4, 48, 22 | 2.80 | 0.001 | 53 | 32 | Right anterior cingulate cortex |
−20, −18, −18 | 2.73 | 0.001 | 41 | 35 | Left hippocampus, parahippocampal gyrus |
−4, 36, 40 | 2.67 | 0.001 | 36 | 32 | Left superior medial frontal gyrus |
MDD>Healthy controls | |||||
26, −90, 14 | −1.81 | ~0 | 731 | 17, 18 | Right superior occipital gyrus, cuneus, middle occipital gyrus |
−10, −96, 12 | −1.03 | <0.001 | 733 | 17, 18 | Left superior occipital gyrus |
44, −50, 26 | −1.33 | <0.001 | 457 | 39 | Right angular gyrus, middle temporal gyrus |
52, −4, 26 | −1.25 | <0.001 | 161 | 4 | Right postcentral gyrus |
