Table 4 Associations between polygenic profile scores of health-related traits created from GWAS consortia summary data, and the UK Biobank tiredness phenotype controlling for age, sex, assessment centre, genotyping batch, and array and 10 principal components for population structure

From: Genetic contributions to self-reported tiredness

Trait category

Trait

Threshold

β

P

Physical health

Blood pressure: diastolic

0.1

−0.0028

0.3619

 

Blood pressure: systolic

0.1

−0.0025

0.4077

 

BMI

1

0.0280

4.90 × 10 − 20 a

 

Cholesterol: HDL

0.5

−0.0163

8.49 × 10 − 8 a

 

Cholesterol: LDL

0.5

0.0081

0.0077 a

 

Coronary artery disease

0.5

0.0084

0.0061

 

C-reactive protein

1

0.0130

2.10 × 10 − 5 a

 

Forced expiratory volume 1 s

0.01

−0.0059

0.0529

 

Longevity

0.05

−0.0067

0.0297

 

HbA1c

1

0.0090

0.0033 a

 

Height

1

−0.0077

0.0154

 

Obesity

1

0.0236

1.20 × 10 − 14 a

 

Rheumatoid arthritis

0.1

−0.0016

0.5926

 

Smoking status

0.5

0.0086

0.0071

 

Triglycerides

0.5

0.0209

1.06 × 10 − 11 a

 

Type 2 diabetes

1

0.0120

0.0002a,b

 

Waist–hip ratio

1

0.0258

7.85 × 10 − 17 a

Mental health

ADHD

1

0.0042

0.1647

 

Alzheimer’s disease

0.05

−0.0052

0.0889

 

Anorexia nervosa

0.5

0.0048

0.1169

 

Autism

1

−0.0018

0.5593

 

Bipolar disorder

0.01

0.0081

0.0076 c

 

Childhood cognitive ability

0.1

−0.0112

0.0002 a

 

Major depressive disorder

1

0.0185

2.25 × 10 − 9 c

 

Neuroticism

0.1

0.0183

2.00 × 10 − 9 c

 

Schizophrenia

1

0.0283

2.31 × 10−19a,c

  1. Abbreviations: ADHD, attention deficit hyperactivity disorder; BMI, body mass index; FDR, false discovery rate; GWAS, genome-wide association study; HDL, high-density lipoprotein; LDL, low-density lipoprotein.
  2. FDR-corrected statistically significant values (P=0.0255) are shown in bold. The associations between the polygenic profile scores with the largest effect size (threshold) and tiredness are presented. Threshold is the P-value threshold with the largest effect size.
  3. aResults remain significant after controlling for neuroticism scores.
  4. bResults remain significant after excluding individuals with type 2 diabetes (β=0.0105, P=0.00076).
  5. cResults remain significant after controlling for self-rated health.
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