Figure 4: Expression analysis in the developing limb and gastrointestinal tract.
From: Human chromosome 21 gene expression atlas in the mouse
a, At E10.5 Tiam1 and Snf1lk are expressed specifically in the apical ectodermal ridge, which is a specialized ectodermal thickening regulating proliferation of the underlying mesoderm (arrows). A more diffuse distribution in the limb bud mesoderm was found for Gart. Erg transcripts are present in the posterior proximal mesoderm at E10.5 and in the joints (red arrows) at E14.5. Adamts1 showed expression in the perichondrium of the developing digits (black arrow). b, Atp50, Cldn8, Ets2 and Clic6 are expressed within the duodenum endoderm. Ets2 transcripts are also detected in the vasculature surrounding the duodenum (arrow). Sod1 mRNA is present in the midgut endoderm and in the stomach endothelium (arrow). Tff3 is transcribed by a subgroup of cells within the gastroduodenal junction region of the pyloric sphincter.
