Table 1 S. mansoni genes that match a human gene with marketed drugs
Gene identifier | Protein description | Potential drugs |
|---|---|---|
Smp_005210 | Histone deacetylase 1 (HDAC1) | Vorinostat‡ |
Smp_009030 | Ribonucleoside-diphosphate reductase, α subunit, putative | Fludarabine phosphate‡ |
Smp_012930 | Inosine-5-monophosphate dehydrogenase, putative | Mycophenolate mofetil†, mycophenolic acid†, ribavirin§ |
Smp_015020 | Na+,K+-ATPase α subunit (SNaK1) | Digoxin‡, digitoxin‡, acetyldigitoxin§, deslanoside§ |
Smp_016780* | Tubulin α chain, putative | Vinblastine†, colchicine†, vincristine† |
Smp_022960 | Aldehyde dehydrogenase, putative | Disulfiram‡ |
Smp_026560 | Calmodulin, putative | Bepridil§ |
Smp_030730* | Tubulin β chain, putative | Colchicine†, vinblastine†, vincristine†, albendazole‡, mebendazole‡, paclitaxel‡, thiabendazole‡, vinorelbine‡, docetaxel§ |
Smp_040130 | Cyclophilin (p17.7) | Cyclosporine† |
Smp_040790 | Cyclophilin B | Cyclosporine† |
Smp_044440 | Alcohol dehydrogenase, putative | Fomepizole† |
Smp_048430 | Thioredoxin glutathione reductase | Auranofin‡ |
Smp_050390 | Aldehyde dehydrogenase, putative | Disulfiram‡ |
Smp_053220 | Aldo-keto reductase, putative | Tolrestat† |
Smp_055890 | Ribonucleoside-diphosphate reductase small chain, putative | Hydroxyurea†, gemcitabine‡ |
Smp_065120 | Deoxyhypusine synthase, putative | Ciclopirox‡ |
Smp_069160 | Cyclophilin, putative | Cyclosporine† |
Smp_079230 | Immunophilin FK506 binding protein FKBP12, putative | Pimecrolimus†, temsirolimus†, sirolimus‡, tacrolimus‡ |
Smp_093280 | Histone deacetylase 3 (HDAC3) | Vorinostat‡ |
Smp_094810 | Cyclophilin E | Cyclosporine† |
Smp_121920 | Vesicular amine transporter, putative | Rauwolfia serpentina‡, reserpine‡, deserpidine§, rescinnamine§, alseroxylon§ |
Smp_135460 | Bifunctional dihydrofolate reductase-thymidylate synthase, putative | Pemetrexed‡, flucytosine‡, floxuridine‡, capecitabine‡, gluorouracil‡ |
Smp_136300 | Tyrosine kinase 5 | Dasatinib‡ |
Smp_147050 | ATP synthase α subunit vacuolar, putative | Tiludronate§ |
Smp_171580 | Aromatic amino acid decarboxylase, putative | Carbidopa‡ |
Smp_173280 | Cyclophilin, putative | Cyclosporine† |
