Figure 2: CA04 sensitivity to antiviral compounds in mice.
From: In vitro and in vivo characterization of new swine-origin H1N1 influenza viruses
Mice were intranasally inoculated with 104 p.f.u. (50 μl) of CA04, KUTK-4 or A/Kawasaki/UTK-23/08 (H1N1). At 1 h after infection, mice were administered oseltamivir phosphate, zanamivir, CS-8958, T-705, or distilled water and PBS (control). Three mice per group were killed on days 3 and 6 after infection and the virus titres in lungs were determined by plaque assays in MDCK cells; results are reported as means ± s.d. The statistical significance of differences in lung virus titres of control mice and those treated with antivirals were assessed by use of the Student’s t-test (asterisk, P < 0.05; double asterisk, P < 0.01).
