Figure 3: The presence of mutational signatures across human cancer types.
Cancer types are ordered alphabetically as columns whereas mutational signatures are displayed as rows. ‘Other’ indicates mutational signatures for which we were not able to perform validation or for which validation failed (Supplementary Figs 24–28). Prevalence in cancer samples indicates the percentage of samples from our data set of 7,042 cancers in which the signature contributed significant number of somatic mutations. For most signatures, significant number of mutations in a sample is defined as more than 100 substitutions or more than 25% of all mutations in that sample. MMR, mismatch repair.
