Extended Data Figure 8: Specificity of CCL2-mediated macrophage recruitment in wild-type and CCR2-morphant larvae
From: Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids
a, Mean macrophage recruitment at 3 hpi into the HBV of control (ctrl), or CCR2-morphant (CCR2) larvae after injection of vehicle control (‘mock’; 0.1% BSA in PBS), human CCL2 (hCCL2), human CCL4 (hCCL4), or human CCL5 (hCCL5). b, c, Mean macrophage (b) and neutrophil (c) recruitment at 3 hpi into the HBV of control (CTRL), CCR2-morphant (CCR2), or MyD88-morphant (MyD88) larvae after injection of vehicle control (mock), murine CCL2 (mCCL2), human CCL2 (hCCL2), human IL-8 (hIL-8), or human LTB4 (hLTB4). Representative of three separate experiments. Significance assessed by one-way ANOVA with Bonferroni’s post-test for the comparisons shown. *P < 0.05; ***P < 0.001.
