Extended Data Figure 7: Selectivity of anti-miR-25 on miR-25 family.
From: Inhibition of miR-25 improves cardiac contractility in the failing heart
Expression levels of miR-25 and family members (miR-32, miR-92a and miR-92b) in sham-operated mice that had been injected with anti-miR-25 or control (scrambled sequence) anti-miRNA as in Fig. 4 (see Methods) (n = 3). n = number of biological replicates (all included). Note that control anti-miRNA in sham-operated animals did not alter expression of any of the miRNAs tested (blue bars). In contrast, anti-miR-25 significantly reduced levels of miR-25 but not other family members in sham-operated animals (red bars). Data are represented as mean ± s.e.m. NS, not significant.
