Extended Data Figure 1: Methodology and UVR spectrum.
From: Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53
a, Schematic representation of experimental schedule, showing induction of BRAF(V600E) by tamoxifen at ∼8 weeks of age followed by weekly exposure to UVR starting 4 weeks later, and for up to 6 months. b, Graph showing spectral radiation distribution for the Waldmann UV6 lamp used in these studies. The UVA and UVB regions are indicated. c, Photomicrograph of Trp53 staining in interfollicular and follicular keratinocytes (arrows) 24 h after UVR exposure. Asterisks indicate hair follicles. Scale bar, 50 μm.
