Extended Data Figure 5: Sunscreen blocks the short-term effects of UVR exposure.
From: Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53
a, Photomicrograph showing lack of Trp53 staining in the cloth-protected (Protected) and UVR-exposed, sunscreen-protected (UVR+SS) skin of a BRAF(V600E) mouse after 24 h of UVR exposure (n = 5). Scale bar, 40 µm. b, Photomicrograph of H&E-stained skin from the cloth protected (Protected) and UVR-exposed, sunscreen-protected (UVR+SS) regions of a BRAF(V600E) mouse after 24 h of UVR exposure. Scale bar, 300 µm. c, High-magnification photomicrograph of H&E-stained skin from the cloth protected (Protected) and UVR-exposed sunscreen-protected (UVR+SS) regions of a BRAF(V600E) mouse after 24 h of UVR exposure showing absence of apoptotic keratinocytes. d, Photomicrograph of H&E-stained skin from a cloth-protected (Protected; left), UVA-exposed (UVA; centre), and UVA-exposed, sunscreen-protected (UVA+SS; right) skin of a mouse after 72 h of UVR exposure. Scale bar, 300 µm (n = 5). The photomicrographs below the main images show areas of higher magnification of the images above. Asterisk indicates epidermal hypertrophy; D indicates plump collagen bundles densely located in the dermis. Scale bar, 150 µm.
