Extended Data Table 3 Summary of Trp53 mutations in UVR-exposed BRAF(V600E) mouse tumours and the TP53 mutation context in humans

From: Ultraviolet radiation accelerates BRAF-driven melanomagenesis by targeting TP53

  1. a, The table summarizes the Trp53 mutations in UVR-exposed mouse tumours, shows Sanger sequencing validation, the UVR-induced mutations, mutation context and records the intensity of Trp53 staining by immunohistochemistry. The table also shows the corresponding human codon and the frequency of somatic mutations at those codons in human cancer (http://p53.iarc.fr/TP53GeneVariations.aspx) and if this codon is mutated in human melanoma. NA, not available. b, The table shows the Trp53 mutations in UVR-exposed BRAF(V600E) tumours, the corresponding human codon, the functional classification based on the SIFT program (SIFT) and the promoter-specific transcriptional activity measured in yeast functional assays and expressed as percentage of wild-type (WT) activity13. c, TP53 mutations occurring at the 3′ end of pyrimidine dimers in human TCGA, Broad Institute and Yale University databases. n, number of human samples with a TP53 mutation (top row) and TP53 mutation at the 3′ end of pyrimidine dimers (bottom row). % indicates column percentage.
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