Extended Data Figure 5: Clonal analysis in K562 cells.
From: Dynamic and static maintenance of epigenetic memory in pluripotent and somatic cells
a, K562 pattern clusters of low methylation regions. Data for three clonal and one polyclonal population are shown. Visualization is as described for Figs 1 and 2. b, Annotation of low methylation K562 pattern clusters. c, High methylation K562 pattern clusters. d, Intermediate methylation pattern clusters. e, Distribution of replication time (K562 Repli-Seq) for the pattern clusters defined earlier. Overall the K562 methylome is defined by the existence of persistent methylation clusters at both the low and high methylation regimes, and by an additional large subset of genomic loci that show highly heterogeneous methylation at late replicating domains.
