Extended Data Figure 8: Cornea epithelium regeneration and repair by transplanted GFP-labelled PAX6⁺ SESCs in a rabbit LSC deficiency model.

a, Time course of corneal epithelial defect repair. Fifteen days post transplantation, there was decreased cornea clarity with an entire corneal epithelial defect evidenced by fluorescein stain of cornea surface; 30 days post transplantation there was improved cornea clarity and reduced fluorescein staining of cornea epithelial defect; 45 and 90 days post transplantation there was restoration and maintenance of cornea clarity. b, c, Two other examples of regeneration and repair of rabbit corneal epithelial surface 90 days post transplantation with GFP-labelled PAX6⁺ SESCs showing complete repair and re-epithelization of corneal epithelial defects. Left panels, white light micrographs; middle panels, slit-lamp micrographs; right panels, fluorescein staining (note that bright spots on the corneal surface were due to camera light reflection, they were not epithelial defects) of corneal epithelium (n = 5). d, H&E stain of regeneration and repair of corneal epithelial surface in three separate rabbits 90 days post transplantation with GFP-labelled PAX6⁺ SESCs showing intact corneal epithelium histology.