Extended Data Figure 6: Stage-specific analysis of higher-order co-associations in the larvae.

For each larval stage of development, binding regions were annotated with binary signatures indicating the presence or absence of factor binding and clustered into SOMs describing the co-association patterns amongst factors assayed in each stage. a–d, SOMs are coloured by the number of factors per co-association pattern with respective patterns in each cluster are indicated underneath. e, For each co-association pattern discovered in stage-specific SOMs, GO enrichment analysis was performed on genes associated by binding within 1 kb of TSSs (ChipPeakAnno)³⁰. GO terms are arranged along the circumference of the graph, and their enrichment is indicated in each stage. The inner-most layer contains the gene ontology colour key as indicated and subsequent layers (from the centre) indicate embryonic (EX), L1, L2, L3 and L4 enrichment of each GO term. For visualization purposes, only GO terms with 5 ≤ annotated genes ≤ 25 (N_GO = 419) are shown.