Figure 3: Stage specificity in higher-order transcription factor co-associations.
From: Regulatory analysis of the C. elegans genome with spatiotemporal resolution
a, Embryonic (EX) and larval L1 binding SOM with raw binding sites. Binding data for factors (N = 15) assayed in embryos and L1 larvae was assigned to 25,261 stage-specific binding modules as shown in the inset. Stage-specific binding modules were clustered into an SOM describing 192 co-association patterns. The SOM is coloured by the embryonic (versus L1) stage specificity of the learned co-association patterns, measured as the fraction of binding modules that are embryonic. b, Histogram of preceding (T1) versus subsequent (T2) stage specificities.
