Extended Data Figure 6: Severe renal disease develops in GaMD-immunized γ−/J-chain− mice.
From: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia
a–c, BALB/c γ1− (12 mice), J-chain− (9 mice) and γ1−/J-chain− (12 mice) mice were injected s.c. with GaMD. a, Urinalysis was performed on the indicated days. b, BUN levels on day 0 and 11. The difference between γ1− and γ1− × J-chain− mice was not consistently observed. c, Survival of GaMD-immunized mice. *P < 0.05.
