Extended Data Figure 8: GaMD-immunized γ1+/− mice generate large IgG3 responses but develop mild renal disease.
From: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia
a, b, BALB/c mice homozygous (γ1+/+), heterozygous (γ1+/−) and null (γ1−/−) for a functional γ1 allele (6 per group) were injected s.c. with GaMD. a, Sera were titred for goat IgG-specific IgG1, IgG2a and IgG3 0, 8 and 12 days later. Day 0 titres were zero for all Ig isotypes (data not shown). b, Urine samples from the same mice were assayed for protein and leukocyte esterase. ND, none detected.
