Extended Data Figure 10: Antigen-specific IgG1 can prevent IgG3 immune complex glomerular deposition.
From: IgG1 protects against renal disease in a mouse model of cryoglobulinaemia
a, b, BALB/c wild-type (WT) mice were injected i.v. with mouse IgG1 and/or IgG3 anti-TNP monoclonal antibody with or without s.c. injection of TNP-BSA on days 0 and 1. a, Kidneys were stained with PAS on day 2. Representative micrographs from 3 mice per group are shown. b, Kidney serial sections were stained with PAS or for IgG3 or IgG1 (brown pigment). Representative micrographs from 4 mice per group are shown. Original magnification, ×200 for a, b.
