Extended Data Figure 2: Pre-catalytic ground state with 8-oxo-dGTP and templating cytosine after a 5 s soak in MnCl2.
From: Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide
a, The pre-catalytic pol β active site is shown with an omit map (3σ). The ground state metal (Mng) has been removed for clarity. b, The view is a 90° rotation relative to a. An overlay of the 8-oxo-dGTP(anti) with Ca2+ and Mn2+ is shown in yellow and purple respectively. The anomalous density map contoured at 5σ for the Mn2+ ions is shown in purple. The Mng coordinating water molecules are shown in blue and the distances (in ångströms) are indicated.
