Extended Data Table 5 Average distances in the active sites in 8-oxo-dGTP(anti) and dGTP(anti)

From: Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide

  1. W(c), W(n), W(g1–g5) are water molecules bound to the Mgc, Mgn and Mgg, respectively. The Mgc in the dGTP(anti) system establishes a new coordination with a water molecular (W(c)*) after 40 ns. The average values are calculated using 50–80 ns range of molecular dynamics trajectories.
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