Extended Data Figure 9: Evolution of RNA binding mitochondrial ribosomal proteins.
From: The complete structure of the large subunit of the mammalian mitochondrial ribosome
a, In the mammalian mitoribosome, the surfaces of mL39 (green) and mL44 (red) corresponding to the RNA binding surfaces of their RNA binding homologues (arrows) are exposed to the solvent. b, The presence of an rRNA expansion segment in the yeast mitoribosome (yeast 21S rRNA5 in orange superimposed on the 39S subunit) explains the arrangement of proteins observed in the mammalian mitoribosome. c, Schematic of the evolution of this region of the mitoribosome. Before the loss of the rRNA expansion segments (ESs), mL39, mL44 and mL57 were possibly simultaneously present in evolutionary precursors of mammalian mitoribosomes.
