Extended Data Figure 7: Additional behavioural data and analyses.
From: Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
a, b, Average response to thermal (Hargrave’s test) and mechanical (Von Frey test) stimuli at 12 weeks after injury (n = 11 naive, 21 vehicle, 10 ILP and 26 ISP for thermal, n = 10 vehicle, 4 ILP and 10 ISP for mechanical). c–e, Correlations between recovery of each individual motor behaviour in the ISP treatment group. f–h, For each behaviour, the ISP-treated animals that recovered to two standard deviations relative to vehicle mean were separated and plotted as ‘responders’ while those that did not were plotted as ‘non-responders’. The n for the responding and non-responding group for each behaviour is listed on the graph. i, An in vivo ISP dose–response plot in a single cohort of animals. A dose-dependent increase occurred in void frequency at 12 weeks after SCI.
