Extended Data Figure 1: Overall WHRadjBMI meta-analysis study design.

Data (dashed lines) and analyses (solid lines) related to the GWAS cohorts for WHRadjBMI are coloured red and those related to the Metabochip (MC) cohorts are coloured blue. The two genomic control (λ_GC) corrections (within-study and among-studies) performed on associations from each data set are represented by grey-outlined circles. The λ_GC corrections for the GWAS meta-analysis were based on all SNPs and the λ_GC corrections for the Metabochip meta-analysis were based on a null set of 4,319 SNPs previously associated with QT interval. The joint meta-analysis of the GWAS and Metabochip data sets is coloured purple. All SNP counts reflect a sample size filter of n ≥ 50,000 subjects. Additional WHRadjBMI meta-analyses included Metabochip data from up to 14,371 subjects of east Asian, south Asian or African-American ancestry from eight cohorts. Counts for the meta-analyses of waist circumference, hip circumference, and their BMI-adjusted counterparts (WCadjBMI and HIPadjBMI) differ from those of WHRadjBMI because some cohorts only had phenotype data available for one type of body circumference measurement (see Supplementary Table 2).