Extended Data Figure 3: Cumulative genetic risk scores for WHRadjBMI applied to the KORA study cohort.
From: New genetic loci link adipose and insulin biology to body fat distribution
a, All subjects (n = 3,440, Ptrend = 6.7 × 10−4). b, Only women (n = 1,750, Ptrend = 1.0 × 10−11). c, Only men (n = 1,690, Ptrend = 0.02). Each genetic risk score illustrates the joint effect of the WHRadjBMI-increasing alleles of the 49 identified variants from Table 1 weighted by the relative effect sizes from the applicable sex-combined or sex-specific meta-analysis. The mean WHRadjBMI residual and 95% confidence interval is plotted for each genetic risk score category (red dots). The histograms show each genetic risk score is normally distributed in KORA (grey bars).
