Extended Data Table 1 WHRadjBMI loci with multiple association signals in the sex-combined and/or sex-specific approximate conditional meta-analyses

From: New genetic loci link adipose and insulin biology to body fat distribution

  1. P values and β coefficients for the association with WHRadjBMI from the joint model in the approximate conditional analysis of combined GWAS and Metabochip studies. SNPs selected by conditional analyses as independently associated with WHRadjBMI in a meta-analysis (sex-combined, women- or men-specific) have their respective summary statistics for these analyses marked in black and bold. SNPs not selected by a particular conditional analysis as independently associated are marked in grey and show the association analysis results for the SNP conditioned on the locus SNPs selected by GCTA. Sample sizes are from the unconditioned meta-analysis.
  2. *Locus and lead SNPs are defined by Table 1.
  3. †The effect allele is the WHRadjBMI-increasing allele in the sex-combined analysis.
  4. ‡Test for sex difference in conditional analysis based on the effect correlation estimate from primary analyses; values significant at the table-wise Bonferroni threshold of 0.05/25 = 2 × 10−3 are marked in bold.
  5. §SNPs selected by conditional analysis in the sex-combined analysis; proxies were selected by joint conditional analysis in the women- and/or men-specific analyses.
  6. ∥SNP not present in the sex-specific meta-analyses due to sample size filter requiring n ≥ 50,000; sample size from GCTA.
  7. ¶At NFE2L3-SNX10, different lead SNPs were identified in the European and all-ancestry analyses but LD is reported with respect to rs10245353.
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