Extended Data Figure 6: Tone-evoked freezing behaviour following inhibition of CeM or NAc projectors during auditory fear conditioning.
From: A circuit mechanism for differentiating positive and negative associations
a, Experimental design. Mice were trained in an auditory fear conditioning paradigm, during which NAc or CeM projectors were selectively inhibited using a dual virus recombination approach (Fig. 3). On the day following conditioning, mice were exposed to eight presentations of the conditioned stimulus alone. They were tethered to a patch cable but no light was delivered. b, Time course of percentage freezing in mice expressing NpHR in NAc projectors (green circles), CeM projectors (red diamonds), or expressing eYFP in NAc or CeM projectors (grey squares) was quantified for each trial. c, There was no significant difference in freezing behaviour in response to the conditioned stimulus among the three groups of mice on test day (one-way ANOVA, F2,38 = 2.010, P = 0.1488). Results show mean and s.e.m.
